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The Sequencing Approach

A war beyond just diagnosis 

Winning a war would require the right strategy, rapid mobilisation of relevant resources and most importantly timely action. 

On Sequencing

So what is the sequencing approach to fight against this pandemic?What can be done?

  • The first requirement is to sequence the genome of all the isolates from infected patients in India
  • COVID-19, is a RNA virus
  • This would require conversion to DNA and then the sequencing of the Alphabets(ATGC) worked out
  • COVID-19 is less than 30kb (30,000) alphabets in size and can be sequences in 24 hours in India
  • Also it needs to be realised that the copying mechanism of RNA to DNA can make errors
  • In any case, it is important to sequence the virus isolates in at least three different institutions in India to ensure that sequencing errors are eliminated
  • A knowledge of genome sequencing is essential to design drugs and vaccines


Comments

  1. Paras MishraApril 1, 2020 at 10:02 AM

    Enjoyed reading the article above , really explains everything in detail,the article is very interesting and effective.Thank you and good luck for the upcoming articles

    ReplyDelete

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